GENOMIC, FUNCTIONAL, AND METABOLIC ENHANCEMENTS IN MULTIDRUG-RESISTANT ENTEROBACTER BUGANDENSIS FACILITATING ITS PERSISTENCE AND SUCCESSION IN THE INTERNATIONAL SPACE STATION

Abstract Background The International Space Station (ISS) stands as a testament to human achievement in space exploration.Despite its highly controlled environment, characterised by microgravity, increased CO $$_{2}$$ 2 levels, and elevated solar radiation, microorganisms occupy a unique niche.These microbial inhabitants play a significant role in

Abstract Type II collagen-positive (Col2+) cells have been reported as skeletal stem cells (SSCs), but the contribution of Col2+ progenitors to skeletal development both prenatally and postnatally during aging remains unclear.To address this question, we generated new mouse models with ablation of Col2+ cells at either the embryonic or postnatal st